![]() Principal Component Analysis (PCA) performed with variables characterizing Ae. Real time quantitative RT-PCR showed the potential involvement of several candidate detoxification genes in insecticide resistance. Molecular screening for common insecticide target-site mutations, revealed the presence of the “knock-down resistance” V1016I Kdr mutation at high frequency (>87%). Biochemical assays showed elevated detoxification enzyme activities of monooxygenases, carboxylesterases and glutathione S-tranferases in most of the populations. Bioassays revealed high levels of resistance to temephos and deltamethrin and susceptibility to Bti in the 9 populations tested. Statistical multifactorial approach was used to investigate the correlations between insecticide resistance levels, associated mechanisms and environmental factors characterizing the mosquito populations. In this study, we investigated the distribution of resistance and the underlying mechanisms in nine Ae. Unfortunately insecticide resistance has already been observed on the Island and recently showed to significantly reduce the efficacy of vector control interventions. ![]() ![]() The most effective proven method for disease prevention has been by vector control by various chemical or biological means. The viruses responsible for dengue are transmitted by Aedes aegypti, an indoor day-biting mosquito. Dengue is an important mosquito borne viral disease in Martinique Island (French West Indies). ![]()
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